Quantifying omics mediation

We used a three-sample Mendelian randomization study design to explore the role of transcript levels in mediating DNA methylation effects on complex traits and diseases.

Sadler, M.C., Auwerx, C., Lepik, K. et al. Quantifying the role of transcript levels in mediating DNA methylation effects on complex traits and diseases. Nat Commun 13, 7559 (2022)