Uromodulin and chronic kidney disease

Using Mendelian randomization, we demonstrate that genetically elevated uromodulin levels have a direct, causal, and adverse effect on kidney function, opposite to the observed correlation.

Ponte, B.*, Sadler, M.C.*, Olinger, E. et al. Mendelian randomization to assess causality between uromodulin, blood pressure, and chronic kidney disease. Kidney Int. 100, 1282-1291 (2021).