Genetic support for drug targets

In this study we compared and benchmarked genetically informed approaches combined with network diffusion to prioritize drug target genes. Gene prioritization methods were based on large-scale GWAS and ExWAS, as well as tissue-wide and whole-blood expression and protein QTLs.

Sadler, M.C., Auwerx, C., Deelen, P. et al. Multi-layered genetic approaches to identify approved drug targets. Cell Genom 3, 7 (2023).