Pharmacogenetics using EHRs

In this study, we analyzed electronic health records in the UK Biobank and All of Us research program to extract drug response phenotypes for ten cardiometabolic medication-biomarker pairs and conduct pharmacogenetics GWAS thereof.

Sadler, M.C., Apostolov, A., Cevallos, C. et al. Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications. Nat Commun 16, 2913 (2025).